Elabscience

GNA12 Polyclonal Antibody

Product Code:
 
E-AB-90662
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using GNA12 Polyclonal Antibody at 1:3000 dilution.
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Western blot analysis of extracts of various cell lines using GNA12 Polyclonal Antibody at 1:3000 dilution.

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CodeSizePrice
E-AB-90662-60uL60uL£210.00
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E-AB-90662-120uL120uL£291.00
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E-AB-90662-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
GNA12
Background:
Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
34kDa/37kDa/44kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000
Immunogen:
Recombinant fusion protein of human GNA12
ObservedMW:
44kDa
Purification method:
Affinity purification
Target Synonym:
GNA12;NNX3;RMP;gep
UNIProt ID:
Q03113

Documents