Elabscience

PDCD1LG2 Polyclonal Antibody

Product Code:
 
E-AB-91960
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Immunofluorescence analysis of HepG2 cells using PDCD1LG2 Polyclonal Antibody at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.
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Immunofluorescence analysis of HepG2 cells using PDCD1LG2 Polyclonal Antibody at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.

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E-AB-91960-60uL60uL£210.00
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E-AB-91960-120uL120uL£291.00
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E-AB-91960-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
PDCD1LG2
Background:
Programmed Death Ligand 2 (PD-L2), also known as B7-DC and butyrophilin-like protein, is a member of the B7 family of proteins that provide signals for regulating T-cell activation and tolerance .PD-L2 is expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites such as rheumatoid arthritis, allergen exposure, and virus infection, PD-L2 is up-regulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand up-regulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.
Buffer:
PBS with 0.05% proclin300,50% glycerol,pH7.3.
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IF 1:50-1:200
Immunogen:
A synthetic peptide of human PDCD1LG2
ObservedMW:
45-60KDa
Purification method:
Affinity purification
Target Synonym:
B7DC;Btdc;CD273;PD-L2;PDCD1L2;PDL2;bA574F11.2;PDCD1LG2
UNIProt ID:
Q9BQ51

Documents