Elabscience

Recombinant Rabbit IL10 protein(His tag)

Product Code:
 
PDMO100002
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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CodeSizePrice
PDMO100002-20ug20ug£269.00
Quantity:
PDMO100002-100ug100ug£397.00
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This product comes from: China.
Typical lead time: 14-21 working days.
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Further Information

Abbreviation:
IL-10
Accession:
Q9TSJ4
Background:
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation.In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling.
Calculated MW:
17.6 kDa
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
17 kDa
Purity:
> 80 % as determined by reducing SDS-PAGE.
Sequence:
Met1-Ser178
Target Synonym:
IL-10;Cytokine synthesis inhibitory factor;CSIF;IL 10
UNIProt ID:
Q9TSJ4

Documents