MUC6 Antibody / Gastric Mucin

Immunohistochemistry (FFPE): 2-4ug/ml for 30 min at RT (1)

Optimal dilution of the recombinant Gastric Mucin antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

MUC6 or gastric mucin is a secreted glycoprotein that plays an essential role in epithelial cyto-protection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2; Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

A peptide from the MUC6 tandem repeat sequence was used as the immunogen for the recombinant Gastric Mucin antibody.

This recombinant Gastric Mucin antibody is available for research use only.

Cytoplasmic & secreted

Protein A affinity chromatography

Q6W4X9