FCGR1A Antibody / CD64

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Three different classes of IgG Fc receptors have been described: Fc gamma RI (CD64), Fc gamma RII (CD32) and Fc gamma RIII (CD16). The low affinity receptors, CD64 and CD16, have a putative role in mediating humoral immune responses. CD64 is a surface glycoprotein with high affinity for monomeric IgG, is expressed constitutively on monocytes and macrophages, and can be induced in neutrophils subsequent to IFN-gamma stimulation. CD64 plays a putative role in the initiation of cell-mediated cytotoxicity. Thus far, three genes encoding four distinct CD64 transcripts have been described. CD64 has been shown to associate with signal transducing subunit of the high affinity IgE receptor. Src family kinases Hck and Lyn show increased kinase activity and will coimmunoprecipitate with CD64 subsequent to receptor cross linking.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the CD64 antibody.

This CD64 antibody is available for research use only.

Cell Membrane

Protein A/G affinity

P12314