ACTN2 Antibody / Alpha Actinin 2 / Sarcomeric Alpha Actinin

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

A portin of amino acids 557-692 from the human protein was used as the immunogen for the recombinant ACTN2 antibody.

This recombinant ACTN2 antibody is available for research use only.

Cytoplasm

Protein A/G affinity

P35609