Phospho-PKCalpha/beta II-T638/641 Rabbit pAb

WB,1:500 - 1:2000 | IHC-P,1:50 - 1:100 | IF/ICC,1:100 - 1:200

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

Unconjugated

PBS with 0.02% sodium azide, 50% glycerol

A synthetic phosphorylated peptide around T638 of human PKCalpha/beta IIPRKCA (NP_002728.2).

76kDa/77kDa

VLTPP