Phospho-Filamin A-S2152 Rabbit pAb

WB,1:500 - 1:2000

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This Protein A Affinity purificationlso contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Unconjugated

PBS with 0.01% thimerosal, 50% glycerol

A synthetic phosphorylated peptide around S2152 of human Filamin A (NP_001104026.1).

281kDa

APSVA