NSJ Bioreagents

Cyclin D1

Product Code:
 
NSJ-F54095
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1849CT557.93.5
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the Cyclin D1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing using Cyclin D1 antibody at 1:2000 : Lane 1) human MCF7, 2) human HT-1080, 3) mouse L929 and 4) mouse NIH3T3 cell lysate. Predicted molecular weight: 32-36 kDa.
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Western blot testing using Cyclin D1 antibody at 1:2000 : Lane 1) human MCF7, 2) human HT-1080, 3) mouse L929 and 4) mouse NIH3T3 cell lysate. Predicted molecular weight: 32-36 kDa.

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CodeSizePrice
NSJ-F54095-0.05ML0.05 ml£260.00
Quantity:
NSJ-F54095-0.2ML0.2 ml£502.00
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Application Details:
WB: 1:2000
Description:
Cyclin D1 / CCND1 is the regulatory component of the Cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. [UniProt]
Format:
Purified
Formulation:
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
Recombinant human Cyclin D1 was used as the immunogen for the Cyclin D1 antibody.
Purity:
Protein G purified
Uniprot #:
P24385