NSJ Bioreagents

Beta Catenin Antibody (C-Terminal Region)

Product Code:
 
NSJ-F54099
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
691CT11.2.1
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Monkey
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the Beta Catenin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
1 / 1
Western blot testing of Beta Catenin antibody at 1:4000: Lane 1) human HEK293, 2) (h) HeLa, 3) monkey COS-7, 4) rat C6 and 5) mouse NIH3T3 cell lysate. Predicted molecular weight ~85 kDa, but routinely observed at 90-95 kDa.
❮❯

Western blot testing of Beta Catenin antibody at 1:4000: Lane 1) human HEK293, 2) (h) HeLa, 3) monkey COS-7, 4) rat C6 and 5) mouse NIH3T3 cell lysate. Predicted molecular weight ~85 kDa, but routinely observed at 90-95 kDa.

No additional charges, what you see is what you pay! *

CodeSizePrice
NSJ-F54099-0.05ML0.05 ml£260.00
Quantity:
NSJ-F54099-0.2ML0.2 ml£502.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Show All

Further Information

Application Details:
WB: 1:4000
Description:
Beta Catenin / CTNNB1 is a key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). [UniProt]
Format:
Purified
Formulation:
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
A portion of amino acids 687-721 from human Beta Catenin was used as the immunogen for the Beta Catenin antibody.
Predicted Species Reactivity:
Bovine
Purity:
Protein G purified
Uniprot #:
P35222