NSJ Bioreagents

SMURF2 Antibody

Product Code:
 
NSJ-F54130
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1826CT865.51.28
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the SMURF2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of SMURF2 antibody at 1:2000: Lane 1) human MDA-MB-231 and 2) U-2OS cell lysate. Predicted molecular weight ~86 kDa.
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Western blot testing of SMURF2 antibody at 1:2000: Lane 1) human MDA-MB-231 and 2) U-2OS cell lysate. Predicted molecular weight ~86 kDa.

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CodeSizePrice
NSJ-F54130-0.05ML0.05 ml£260.00
Quantity:
NSJ-F54130-0.2ML0.2 ml£502.00
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Application Details:
WB: 1:2000-1:4000
Description:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level. [UniProt]
Format:
Purified
Formulation:
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
Recombinant human SMURF2 was used as the immunogen for the SMURF2 antibody.
Purity:
Protein G purified
Uniprot #:
Q9HAU4