NSJ Bioreagents

STUB1 Antibody (C-Terminal Region)

Product Code:
 
NSJ-F54140
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1008CT12.4.1
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Application:
 
Western Blot (WB)
Storage:
 
Aliquot the STUB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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Western blot testing of STUB1 antibody at 1:4000: Lane 1) human HEK293, 2) HeLa, 3) HepG2 and 4) mouse L929 cell lysate. Predicted molecular weight ~35 kDa.
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Western blot testing of STUB1 antibody at 1:4000: Lane 1) human HEK293, 2) HeLa, 3) HepG2 and 4) mouse L929 cell lysate. Predicted molecular weight ~35 kDa.

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CodeSizePrice
NSJ-F54140-0.05ML0.05 ml£260.00
Quantity:
NSJ-F54140-0.2ML0.2 ml£502.00
Quantity:
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Further Information

Application Details:
WB: 1:4000
Description:
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. [UniProt]
Format:
Purified
Formulation:
In 1X PBS, pH 7.4, with 0.09% sodium azide
Immunogen:
Recombinant human STUB1 was used as the immunogen for the STUB1 antibody.
Purity:
Protein G purified
Uniprot #:
Q9UNE7