NSJ Bioreagents

PILRA Antibody / Paired immunoglobulin-like type 2 receptor alpha

Product Code:
 
NSJ-RQ8058
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Fluorescence-activated cell sorting (FACS)
  • Western Blot (WB)
Storage:
 
After reconstitution, the PILRA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
1 / 2
Flow cytometry testing of fixed and permeabilized human HEL cells with PILRA antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= PILRA antibody.
2 / 2
Western blot testing of human 1) HeLa and 2) Jurkat cell lysate with PILRA antibody. Predicted molecular weight ~34 kDa but may be observed at higher molecular weights due to glycosylation.
❮❯

Flow cytometry testing of fixed and permeabilized human HEL cells with PILRA antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= PILRA antibody.
Western blot testing of human 1) HeLa and 2) Jurkat cell lysate with PILRA antibody. Predicted molecular weight ~34 kDa but may be observed at higher molecular weights due to glycosylation.

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CodeSizePrice
NSJ-RQ8058-100ug100 ug£535.00
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Further Information

Application Details:
Western blot: 0.5-1ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml
Description:
Paired immunoglobin like type 2 receptor alpha is a protein that in humans is encoded by the PILRA gene. Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Format:
Antigen affinity purified
Formulation:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
E. coli-derived recombinant human protein (amino acids T154-A303) was used as the immunogen for the PILRA antibody.
Purity:
Antigen affinity purified
Uniprot #:
Q9UKJ1