NSJ Bioreagents

PSMC5 Antibody / 26S proteasome regulatory subunit 8

Product Code:
 
NSJ-RQ8130
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
After reconstitution, the PSMC5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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Western blot testing of 1) human CCRF-CEM, 2) human MOLT4, 3) human SK-O-V3, 4) human MCF7, 5) rat kidney, 6) rat PC-12, 7) mouse kidney and 8) mouse NIH 3T3 cell lysate with PSMC5 antibody. Predicted molecular weight ~46 kDa.
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Western blot testing of 1) human CCRF-CEM, 2) human MOLT4, 3) human SK-O-V3, 4) human MCF7, 5) rat kidney, 6) rat PC-12, 7) mouse kidney and 8) mouse NIH 3T3 cell lysate with PSMC5 antibody. Predicted molecular weight ~46 kDa.

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NSJ-RQ8130-100ug100 ug£535.00
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Further Information

Application Details:
Western blot: 0.5-1ug/ml,Direct ELISA: 0.1-0.5ug/ml
Description:
26S protease regulatory subunit 8, also known as 26S proteasome AAA-ATPase subunit Rpt6, is an enzyme that in humans is encoded by the PSMC5 gene. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
Format:
Antigen affinity purified
Formulation:
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Immunogen:
E. coli-derived recombinant human protein (amino acids E29-K393) was used as the immunogen for the PSMC5 antibody.
Purity:
Antigen affinity purified
Uniprot #:
P62195