NSJ Bioreagents

Recombinant Granzyme B Antibody

Product Code:
 
NSJ-V9508
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Rabbit
Antibody Isotype:
 
Rabbit IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
GZMB/4539R
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
 
Aliquot the recombinant Granzyme B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
1 / 4
Western blot testing of human spleen tissue lysate using recombinant Granzyme B antibody (clone GZMB/4539R). Predicted molecular weight: 29-37 kDa.
2 / 4
IHC staining of FFPE human spleen tissue with recombinant Granzyme B antibody (clone GZMB/4539R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
3 / 4
IHC staining of FFPE human tonsil tissue with recombinant Granzyme B antibody (clone GZMB/4539R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
4 / 4
SDS-PAGE analysis of purified, BSA-free recombinant Granzyme B antibody (clone GZMB/4539R) as confirmation of integrity and purity.
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Western blot testing of human spleen tissue lysate using recombinant Granzyme B antibody (clone GZMB/4539R). Predicted molecular weight: 29-37 kDa.
IHC staining of FFPE human spleen tissue with recombinant Granzyme B antibody (clone GZMB/4539R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human tonsil tissue with recombinant Granzyme B antibody (clone GZMB/4539R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free recombinant Granzyme B antibody (clone GZMB/4539R) as confirmation of integrity and purity.

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CodeSizePrice
NSJ-V9508-20UG20 ug£264.00
Quantity:
NSJ-V9508-100UG100 ug£534.00
Quantity:
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This product comes from: United States.
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Further Information

Application Details:
Western blot: 2-4ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml
Description:
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A portion of amino acids 73-187 was used as the immunogen for the recombinant Granzyme B antibody.
Localisation:
Cytoplasm
Purity:
Protein A/G affinity
Uniprot #:
P10144