NSJ Bioreagents

IGFBP3 Antibody

Product Code:
 
NSJ-V9555SAF
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2b, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
IGFBP3/3424
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Fluorescence-activated cell sorting (FACS)
  • Immunofluorescence (IF)
Storage:
 
Aliquot the IGFBP3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
1 / 3
Immunofluorescent staining of PFA-fixed U-87 MG cells using IGFBP3 antibody (green, clone IGFBP3/3424) and phalloidin (red).
2 / 3
FACS staining of PFA-fixed human U-87 MG cells with IGFBP3 antibody (blue, clone IGFBP3/3424) and isotype control (red).
3 / 3
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using IGFBP3 antibody (clone IGFBP3/3424). These results demonstrate the foremost specificity of the IGFBP3/3424 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
❮❯

Immunofluorescent staining of PFA-fixed U-87 MG cells using IGFBP3 antibody (green, clone IGFBP3/3424) and phalloidin (red).
FACS staining of PFA-fixed human U-87 MG cells with IGFBP3 antibody (blue, clone IGFBP3/3424) and isotype control (red).
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using IGFBP3 antibody (clone IGFBP3/3424). These results demonstrate the foremost specificity of the IGFBP3/3424 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

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NSJ-V9555SAF-100UG100 ug£534.00
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Further Information

Application Details:
Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml
Description:
The Insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, as well as their concentration and distribution in the extracellular environment. In addition, the IGFBPs appear to have biological activity independent of the IGFs. Seven IGFBPs have thus far been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
Recombinant human full-length IGFBP3 protein was used as the immunogen for the IGFBP3 antibody.
Localisation:
Cytoplasm, Nucleus
Purity:
Protein A/G affinity
Uniprot #:
P17936