NSJ Bioreagents

Interleukin 6 Receptor subunit beta Antibody / IL6ST / CD130

Product Code:
 
NSJ-V9656
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG2b, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
IL6ST/4101
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry- Paraffin Embedded (IHC-P)
Storage:
 
Aliquot the Interleukin 6 Receptor subunit beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
1 / 2
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Interleukin 6 Receptor subunit beta antibody (clone IL6ST/4101). These results demonstrate the foremost specificity of the IL6ST/4101 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
2 / 2
IHC staining of FFPE human adrenal gland tissue with Interleukin 6 Receptor subunit beta antibody (clone IL6ST/4101). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
❮❯

Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Interleukin 6 Receptor subunit beta antibody (clone IL6ST/4101). These results demonstrate the foremost specificity of the IL6ST/4101 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
IHC staining of FFPE human adrenal gland tissue with Interleukin 6 Receptor subunit beta antibody (clone IL6ST/4101). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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NSJ-V9656-20UG20 ug£264.00
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NSJ-V9656-100UG100 ug£534.00
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Further Information

Application Details:
Immunohistochemistry (FFPE): 1-2ug/ml
Description:
IL6ST is a signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. [UniProt]
Format:
Purified
Formulation:
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Immunogen:
A recombinant fragment of the human protein corresponding to the extracellular domain was used as the immunogen for the Interleukin 6 Receptor subunit beta antibody.
Purity:
Protein A/G affinity
Uniprot #:
P40189