TargetMol

Thujopsene

Product Code:
 
TAR-TN7505
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
 

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TAR-TN7505-10mg10mgEnquire
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Further Information

Bioactivity:
Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 ug/ml and Ki of 0.8 uM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 ug/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-sensitized RBL-2H3 mast cells (IC50= 25.1 uM) and shows cytotoxicity against A549 non-small cell lung cancer cells with an LC50 of 35.27 ug/ml. Furthermore, thujopsene causes mortality in mites D. farinae and T. putrescentiae, with LC50s of 9.82 and 10.92 ug/cm2, respectively.
CAS Number:
470-40-6
Purity:
98%

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