TargetMol

GRK6 Protein, Human, Recombinant (His & GST)

Product Code:
 
TAR-TMPY-04409
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPY-04409-50ug50ugEnquire
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  • Further Information
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Further Information

Bioactivity:
G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6, and GPRK6, is a lipid-anchor protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain, and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described. GRK6 / GPRK6 is widely expressed. GRK6 / GPRK6 silencing causes suppression of signal transducer and activator of transcription 3 (STAT3) phosphorylation associated with a reduction in MCL1 levels and phosphorylation, illustrating a potent mechanism for the cytotoxicity of GRK6 inhibition in multiple myeloma (MM) tumor cells. GRK6 also appears to be involved in responses to morphine. Inhibition of GRK6 represents a uniquely targeted novel therapeutic strategy in human multiple myeloma.
Molecular Weight:
95.1 kDa (predicted)
Purity:
98%

References

1.Ghadessy,R.S. et al., 2003, Br J Pharmacol??138?(4):660-70. 2.Murga,C. et al., 2009, Brain Behav Immun. 23?(1):16-7. 3.Tiedemann,R.E.?et al., 2010, Blood??115?(8):1594-604. 4.Ahmed,M.R. et al., 2010, Sci Transl Med?2?(28): 28ra28.