TargetMol

CD45 Protein, Human, Recombinant (His & Avi)

Product Code:
 
TAR-TMPK-00423
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-00423-100ug100ugEnquire
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TAR-TMPK-00423-1mg1mgEnquire
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TAR-TMPK-00423-500ug500ugEnquire
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Further Information

Bioactivity:
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 47.3 kDa and the accession number is P08575-4.
Molecular Weight:
47.3 kDa (predicted). Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Courtney AH, et al. CD45 functions as a signaling gatekeeper in T cells. Sci Signal. 2019 Oct 22;12(604):eaaw815doi: 10.1126/scisignal.aaw815PMID: 31641081; PMCID: PMC6948007.