TargetMol

SARS-COV-2 Spike S1 Protein (D614G, His & Avi)

Product Code:
 
TAR-TMPK-00436
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-00436-100ug100ugEnquire
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TAR-TMPK-00436-1mg1mgEnquire
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  • Further Information
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Further Information

Bioactivity:
The SARS-CoV-2 spike (S) protein is the target of vaccine design efforts to end the COVID-19 pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic, and are now the dominant form worldwide. Here, we analyze the D614G mutation in the context of a soluble S ectodomain construct.
Molecular Weight:
77.9 kDa (predicted). Due to glycosylation, the protein migrates to 110-120 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Zhang L, et al. The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity. bioRxiv [Preprint]. 2020 Jun 12:2020.06.12.148726. doi: 10.1101/2020.06.12.148726. Update in: Nat Commun. 2020 Nov 26;11(1):6013. PMID: 32587973; PMCID: PMC731063