TargetMol

TREM2 Protein, Cynomolgus, Recombinant (His)

Product Code:
 
TAR-TMPK-00507
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-00507-100ug100ugEnquire
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TAR-TMPK-00507-1mg1mgEnquire
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  • Further Information
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Further Information

Bioactivity:
TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2? consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.
Molecular Weight:
18.5 kDa (predicted). Due to glycosylation, the protein migrates to 33-42 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Ford J W, Mcvicar D W. TREM and TREM-like receptors in inflammation and disease[J]. Current Opinion in Immunology, 2009, 21(1):38-46.