TargetMol

SEZ6 Protein, Mouse, Recombinant (His)

Product Code:
 
TAR-TMPK-01065
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01065-100ug100ugEnquire
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TAR-TMPK-01065-1mg1mgEnquire
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TAR-TMPK-01065-500ug500ugEnquire
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Further Information

Bioactivity:
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 98.8 kDa and the accession number is Q7TSK2.
Molecular Weight:
98.8 kDa (predicted). Due to glycosylation, the protein migrates to 145-150 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Roitman M, et al. Sez6 levels are elevated in cerebrospinal fluid of patients with inflammatory pain-associated conditions. Pain Rep. 2019 Mar 25;4(2):e719. doi: 10.1097/PR9.0000000000000719. PMID: 31041421; PMCID: PMC6455686.