TargetMol

LGMN Protein, Human, Recombinant (His)

Product Code:
 
TAR-TMPK-01146
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-TMPK-01146-100ug100ugEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-TMPK-01146-1mg1mgEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-TMPK-01146-500ug500ugEnquire
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.
Molecular Weight:
48.6 kDa (predicted). Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Zhang X, et al. Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population. Eur J Neurosci. 2020 Oct;52(8):4009-4017. doi: 10.1111/ejn.14857. Epub 2020 Jun 28. PMID: 32506655.