TargetMol

CHRDL1 Protein, Human, Recombinant (His)

Product Code:
 
TAR-TMPK-01152
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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TAR-TMPK-01152-100ug100ugEnquire
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-TMPK-01152-1mg1mgEnquire
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TAR-TMPK-01152-500ug500ugEnquire
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant.
Molecular Weight:
50 kDa (predicted) same as Tris-Bis PAGE result.
Purity:
98%

References

1.Pei YF, et al. Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer. Oncotarget. 2017 Apr 4;8(14):23155-23166. doi: 10.18632/oncotarget.15513. Erratum in: Oncotarget. 2017 Jul 18;8(29):48526. Wu, Ding-Wei [corrected to Wu, Wei-ding]. PMID: 28423564; PMCID: PMC5410293.