TargetMol

PLVAP Protein, Human, Recombinant (His)

Product Code:
 
TAR-TMPK-01153
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-TMPK-01153-100ug100ugEnquire
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TAR-TMPK-01153-1mg1mgEnquire
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TAR-TMPK-01153-500ug500ugEnquire
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  • Further Information
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Further Information

Bioactivity:
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases.
Molecular Weight:
45.97 kDa (predicted). Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
Purity:
98%

References

1.Nakagami Y, et al. An anti-PLVAP antibody suppresses laser-induced choroidal neovascularization in monkeys. Eur J Pharmacol. 2019 Jul 5;854:240-246. doi: 10.1016/j.ejphar.2019.04.035. Epub 2019 Apr 23. PMID: 31026444.