TargetMol

ECSIT Protein, Human, Recombinant (His)

Product Code:
 
TAR-TMPY-03606
Product Group:
 
Recombinant Proteins
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20°C
1 / 1
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CodeSizePrice
TAR-TMPY-03606-100ug100ugEnquire
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  • Further Information
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Further Information

Bioactivity:
ECSIT is an adapter protein of the toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. It bridges TRAF6 to MEKK-1. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-kappaB. ECSIT is also required for normal embryonic development and efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase.
Molecular Weight:
22.9 kDa (predicted)
Purity:
98%

References

1.Kopp E. et al., 1999, Genes Dev. 13 (16): 2059-71. 2.The MGC Project Team. 2004, Genome Res. 14: 2121-7. 3.Vogel RO. et al., 2007, Genes Dev. 21: 615-24.