MD2/LY96 Protein, Mouse, Recombinant (hFc)

Product Code:

TAR-TMPY-03999

Product Group:

Recombinant Proteins

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20°C

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Code	Size	Price

TAR-TMPY-03999-100ug

100ug

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Further Information

Bioactivity:

LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activation of NF-kappa-B. ESOP-1 has 16 amino acids, the sequence of which shows 64% identity with human ESOP-1/MD-2. ESOP-1 mRNA is highly expressed in the mouse embryos at 7.5 days after coitus. Diseases associated with LY96 include Melioidosis and Intestinal Botulism.

Molecular Weight:

43.4 kDa (predicted)

Purity:

98%

References

1.Shimazu R.,et al.,(1999), MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777-1782. 2.Kato K.,et al., (2000), ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice.Blood 96:362-364. 3.Schromm A.B.,et al.,(2001), Molecular genetic analysis of an endotoxin nonresponder mutant cell line. A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.J. Exp. Med. 194:79-88.