AdipoGen Life Sciences

anti-CD137L (human), mAb (41B436)

Product Code:
 
AG-20A-0031
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
41B436
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Flow Cytometry
  • Western Blot (WB)
Shipping:
 
Blue Ice
Storage:
 
-20°C
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FACS: Human CD137L-transfected HEK 293 cells were stained significantly using anti-CD137L (human), mAb (41B436) (Prod. No. AG-20A-0031). No binding was detected on empty vector transfected cells.
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FACS: Human CD137L-transfected HEK 293 cells were stained significantly using anti-CD137L (human), mAb (41B436) (Prod. No. AG-20A-0031). No binding was detected on empty vector transfected cells.

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AG-20A-0031-C05050 ug£195.00
Quantity:
AG-20A-0031-C100100 ug£249.00
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Further Information

Alternate Names/Synonyms:
4-1BBL; TNFSF9
Concentration:
1mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant human CD137L extracellular domain.
Long Description:
Monoclonal Antibody. Recognizes extracellular domain of human CD137L. Does not cross-react with mouse CD137L. Isotype: Mouse IgG1kappa. Clone: 41B436. Applications: ELISA, FACS, ICC, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
NCBI, Uniprot Number:
P41273
Package Type:
Plastic Vial
Product Description:
The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.
Specificity:
Recognizes extracellular domain of human CD137L. Does not cross-react with mouse CD137L.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling: C. Gullo, et al.; PLoS One. 5, e10845 (2010) | Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling: M.C. Moh, et al.; FASEB J. 27, 2957 (2013) | Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression: W.T. Ho, et al.; Cancer Res. 73, 652 (2013)