anti-AIM2 (human) mAb (3B10)

Product Code:

AG-20B-0040

Product Group:

Primary Antibodies

Supplier:

AdipoGen Life Sciences

Host Type:

Mouse

Antibody Isotype:

IgG1

Antibody Clonality:

Monoclonal

Antibody Clone:

3B10

Regulatory Status:

RUO

Target Species:

Human

Applications:

Immunocytochemistry (ICC)
Western Blot (WB)

Shipping:

-20°C

Storage:

-20°C

No additional charges, what you see is what you pay! *

Code	Size	Price

AG-20B-0040-C100

100 ug

£230.00

Quantity:

Prices exclude any Taxes / VAT

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Further Information

Alternate Names/Synonyms:

Interferon-inducible Protein AIM2; Absent in Melanoma 2

Concentration:

1 mg/ml

EClass:

32160000

Form (Short):

liquid

Formulation:

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Handling Advice:

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Immunogen:

Human AIM2 (aa 1-186).

Long Description:

Monoclonal Antibody. Recognizes human AIM2. Isotype: Mouse IgG1. Clone: 3B10. Applications: ICC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.

NCBI, Uniprot Number:

O14862

Package Type:

Plastic Vial

Product Description:

AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16 [8], MNDA [9], AIM2 [1] and IFIXl. Recently it has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms a novel inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1beta.

Purity:

>95% (SDS-PAGE)

Source / Host:

Purified from concentrated hybridoma tissue culture supernatant.

Specificity:

Recognizes human AIM2.

Transportation:

Non-hazardous

UNSPSC Category:

Primary Antibodies

UNSPSC Number:

12352203

Use & Stability:

Stable for at least 1 year after receipt when stored at -20°C.

Documents

References

Expression of IFI 16 in epithelial cells and lymphoid tissues: W. Wei, et al.; Histochem. Cell Biol. 119, 45 (2003) | Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2: K.S. Cresswell, et al.; BBRC 326, 417 (2005) | AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA: T. Fernandes-Alnemri, et al.; Nature 458, 509 (2009) | AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC: V. Hornung, et al.; Nature 458, 514 (2009) | A novel flow cytometric method to assess inflammasome formation: D.P. Sester, et al.; J. Immunol. 194, 455 (2015) | Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection: C. Sun, et al.; J. Immunol. 194, 1819 (2015) | Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication: Y. Maruzuru, et al.; Cell Host Microbe. 23, 254 (2018) | PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells: D. Massa, et al.; J. Biol. Chem. 295, 4438 (2020)