anti-APRIL (mouse) mAb (rec.) (blocking) (Apry-1-1) (Biotin)
Product Code:
AG-27B-0001B
AG-27B-0001B
Host Type:
Mouse
Mouse
Antibody Isotype:
IgG2bλ
IgG2bλ
Antibody Clonality:
Monoclonal
Monoclonal
Antibody Clone:
APRY-1-1
APRY-1-1
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Functional Study
- Immunoprecipitation (IP)
Shipping:
-20°C
-20°C
Storage:
-20°C
-20°C
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| Code | Size | Price |
|---|
| AG-27B-0001B-C100 | 100 ug | £360.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
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- Further Information
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Further Information
Alternate Names/Synonyms:
A Proliferation Inducing Ligand; TNFSF13; CD256; TALL-2
Concentration:
0.5mg/ml
EClass:
32160000
Endotoxin:
<0.1EU/µg purified protein (LAL-test; Lonza)
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Mouse APRIL (aa 98-232).
Labels - Conjugates:
Biotin
Long Description:
Recombinant Antibody. Recognizes mouse APRIL. Does not recognize mouse BAFF. Species cross-reactivity: Mouse. Clone: Apry-1-1. Isotype: Mouse IgG2blambda. Applications: ELISA, FUNC (Blocking), IP. Host: Purified from HEK 293 cell culture supernatant. Liquid. In PBS containing 0.02% sodium azide. APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth and is involved in monocyte/macrophage-mediated immunological processes. Anti-APRIL (mouse) Monoclonal Antibody (recombinant) (Blocking) (APRY-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
NCBI, Uniprot Number:
Q9D777
Other data:
APRIL (mouse) monoclonal antibody (recombinant) (blocking) (APRY-1-1) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the mouse lgG2b Fc domain.
Package Type:
Plastic Vial
Product Description:
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth and is involved in monocyte/macrophage-mediated immunological processes. Anti-APRIL (mouse) Monoclonal Antibody (recombinant) (Blocking) (APRY-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
Purity:
>95% (SDS-PAGE)
Source / Host:
Produced without the use of animals. Purified from HEK 293 cell culture supernatant.
Specificity:
Recognizes mouse APRIL. Does not recognize mouse BAFF.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibody Conjugates
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 month after receipt when stored at +4°C. Stable for at least 1 year after receipt when stored at -20°C.
Documents
References
Production of the plasma-cell survival factor APRIL peaks in myeloid precursor cells from human bone marrow: T. Matthes, et al.; Blood 118, 1838 (2011) | Pathogenic role of a proliferation-inducing ligand (APRIL) in murine IgA nephropathy: Y.G. Kim, et al.; PLoS One 10, e0137044 (2015) | The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis: T. Abe, et al.; J. Immunol. 195, 1427 (2015) | Splenic marginal zone granulocytes acquire an accentuated neutrophil B-cell helper phenotype in chronic lymphocytic leukemia: M. Gaetjen, et al.; Cancer Res. 76, 5253 (2016) | A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells: P. Haselmayer, et al.; Eur. J. Immunol. 47, 1075 (2017) (+Supplement) | Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells: Y. Zhang, et al.; J. Exp. Med. 215, (2018) | Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis: H.-Y. Huang, et al.; PNAS 115, E6826 (2018) | APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans: D. Tsiantoulas, et al.; Nature 597, 92 (2021)