Chimerigen

CD273 [PD-L2] (human):Fc (human) (rec.) (non-lytic)

Product Code:
 
CHI-HF-220PDL2
Product Group:
 
Recombinant Proteins
Supplier:
 
Chimerigen
Host Type:
 
Hamster
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
BI
Storage:
 
-20°C
 

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CHI-HF-220PDL2-C100100 ug£385.00
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Further Information

Alternate Names/Synonyms:
PD-L2; Programmed Cell Death 1 Ligand 2; PDCD1 Ligand 2; B7-DC; PDL2
Biological Activity:
Shows the biological function of the CD273 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.
EClass:
32160000
Endotoxin:
<0.06EU/µg protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of a mutant human IgG1. Source: CHO cells. Endotoxin content: <0.06EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >98% (SDS-PAGE). T cells require a signal induced by the engagement of the T cell receptor and a ?costimulatory? signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
NCBI, Uniprot Number:
NP_079515.2
Package Type:
Plastic Vial
Product Description:
T cells require a signal induced by the engagement of the T cell receptor and a ?costimulatory? signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 [PD-L2] is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
Purity:
>98% (SDS-PAGE)
Sequence:
The extracellular domain of human CD273 [PD-L2] (aa 20-219) is fused to the N-terminus of the Fc region of a mutant human IgG1.
Source / Host:
CHO cells
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.