CD275 [B7-H2] (mouse):Fc (mouse) (rec.) (non-lytic)
Product Code:
CHI-MF-120B7H2
CHI-MF-120B7H2
Regulatory Status:
RUO
RUO
Target Species:
Mouse
Mouse
Shipping:
BI
BI
Storage:
-20°C
-20°C
No additional charges, what you see is what you pay! *
| Code | Size | Price |
|---|
| CHI-MF-120B7H2-C100 | 100 ug | £395.00 |
Quantity:
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This product comes from: Switzerland.
Typical lead time: 7-10 working days.
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Typical lead time: 7-10 working days.
Contact us for more accurate information.
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Further Information
Alternate Names/Synonyms:
B7-H2; ICOS Ligand; B7-like Protein Gl50; B7RP-1
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human ICOS at 1µg/ml (100µl/well) can bind biotinylated B7-H2 (mouse):Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0µg/ml. Optimal dilutions should be determined by each laboratory for each application.
EClass:
32160000
Endotoxin:
<0.06EU/µg protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. The extracellular domain of mouse CD275 [B7-H2] (aa 48-279) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgammaR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC). Purity: >98% (SDS-PAGE). Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
NCBI, Uniprot Number:
NP_056605.1
Package Type:
Plastic Vial
Product Description:
Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
Purity:
>98% (SDS-PAGE)
Sequence:
The extracellular domain of mouse CD275 [B7-H2] (aa 48-279) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.
Source / Host:
CHO cells
Specificity:
Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgammaR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
TAGs:
Fc
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.