JaICA

anti-Nitrotryptophan (NW), mAb (117C)

Product Code:
 
JAI-MNW-020P
Product Group:
 
Primary Antibodies
Supplier:
 
JaICA
Antibody Isotype:
 
Mouse IgG1?
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
117C
Regulatory Status:
 
RUO
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
BI
Storage:
 
-20°C
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Chemical structure of 6-Nitrotryptophan.
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Chemical structure of 6-Nitrotryptophan.

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JAI-MNW-020P-20ug20 ug£233.00
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Further Information

Concentration:
100µg/ml of IgG in 10mM PBS (pH 7.4).
EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized.
Handling Advice:
Avoid freeze/thaw cycles.
Immunogen:
6-Nitrotryptophan modified Keyhole Limpet Hemocyanin (KLH).
Long Description:
Monoclonal Antibody. Recognizes 6-Nitrotryptophan. Lyophilized. Contains 10mM PBS (pH 7.4). Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.
Package Type:
Plastic Vial
Product Description:
Reactive nitrogen species (RNS) are formed in a variety of diseases such as atherosclerosis, inflammation, cancer and neurodegenerative diseases. Peroxinitrite (ONOO-) is known as a potent biological oxidant, which is formed via very fast reaction between nitric oxide (NO) and superoxide (O2-). Peroxinitrite can induce nitration of aromatic amino acids such as Tyr, Trp, Phe and His, which results in modulation of protein functions. To date, 6-nitrotryptophan (6-NO2-Trp) is shown to be one of the most stable and major peroxynitrite-modified amino acids, and growing evidences suggest that nitrotryptophan may play a significant role in the cellular regulation under nitrosative stress. This antibody is suitable for immunohistochemistry, western blotting and ELISA and may provide a powerful tool for the investigation of nitrosative stress inside living bodies.
Purity:
Protein A purified.
Specificity:
Recognizes 6-Nitrotryptophan.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibodies
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 3 years after receipt when stored at -20°C.

References

Proteomic analysis of endogeneous nitrotryptophan-containing proteins in rat hippocampus and cerebellum: M. Uda, et al.; Bioci. Rep. 32, 521 (2012)