ProSci

IL-28B Antibody

Product Code:
 
PSI-7479
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Western Blot (WB)
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Western blot analysis of IL-28B in HeLa cell lysate with IL-28B antibody at (A) 1 and (B) 2 μg/ml.
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Immunofluorescence of IL-28B in HeLa cells with IL-28B antibody at 5 μg/mL.
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Western blot analysis of IL-28B in HeLa cell lysate with IL-28B antibody at (A) 1 and (B) 2 μg/ml.
Immunofluorescence of IL-28B in HeLa cells with IL-28B antibody at 5 μg/mL.

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CodeSizePrice
PSI-7479-0.02mg0.02mg£150.00
Quantity:
PSI-7479-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
IL-28B Antibody : IL28B, IL28C, IL-28B, IL28B, ZCYTO22, Interferon lambda-3, Cytokine Zcyto22, IFN-lambda-3
Application Note:
IL-28B antibody can be used for detection of IL-28B by Western blot at 1 - 2 μg/ml.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
Interleukin 28 (IL-28B), also known as interferon lambda 3, is cytokine distantly related to type I interferons and the IL-10 family (1). The IL-28B gene and the closely related cytokine genes IL-28A and IL-29 form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection and can induce anti-viral activity (2,3). All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor-beta (IL10RB) and interleukin 28 receptor- alpha (IL28RA) (1).
Background References:
  • Sheppard P, Kindsvogel W, Xu W, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat. Immunol. 2003; 4:63-8.
  • Osterlund PI, Pietila TE, Veckman V, et al. IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J. Immunol. 2007; 179:3434-42.
  • Meager A, Visvalingam K, Dilger P, et al. Biological activity of interleukins-28 and -29: comparison with type I interferons. Cytokine 2005; 31:109-18.
Buffer:
IL-28B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IL-28B antibody was raised against a 17 amino acid peptide near the center of human IL-28B.

The immunogen is located within amino acids 120 - 170 of IL-28B .
NCBI Gene ID #:
282617
NCBI Official Name:
interferon, lambda 3
NCBI Official Symbol:
IFNL3
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 20 kDa

Observed: 16kDa
Protein Accession #:
NP_742151
Protein GI Number:
28144901
Purification:
IL-28B Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
SPECIFICITY:
IL-28B antibody is human specific. IL-28B antibody may cross-react with IL-28A and IL-29.
Swissprot #:
Q8IZI9
User NOte:
Optimal dilutions for each application to be determined by the researcher.