ProSci

DNM1L Antibody

Product Code:
 
PSI-7603
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
1 / 3
Western blot analysis of DNM1L in HeLa cell lysate with DNM1L antibody at 1 μg/ml.
2 / 3
Immunocytochemistry of DNM1L in HeLa cells with DNM1L antibody at 5 μg/mL.
3 / 3
Immunofluorescence of DNM1L in HeLa cells with DNM1L antibody at 20 μg/mL.
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Western blot analysis of DNM1L in HeLa cell lysate with DNM1L antibody at 1 μg/ml.
Immunocytochemistry of DNM1L in HeLa cells with DNM1L antibody at 5 μg/mL.
Immunofluorescence of DNM1L in HeLa cells with DNM1L antibody at 20 μg/mL.

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CodeSizePrice
PSI-7603-0.02mg0.02mg£150.00
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PSI-7603-0.1mg0.1mg£449.00
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Further Information

Additional Names:
DNM1L Antibody: DLP1, DRP1, DVLP, EMPF, DYMPLE, HDYNIV, DLP1, Dynamin-1-like protein, Dynamin family member proline-rich carboxyl-terminal domain less
Application Note:
DNM1L antibody can be used for detection of DNM1L by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
The Dynamin-1-like protein (DNM1L) is a member of the dynamin superfamily of GTPases (1). DNM1L mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis (2). Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF) (3).
Background References:
  • Shin HW, Shinotsuka C, Torii S, et al. Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p. J. Biochem. 1997; 122:525-30.
  • Frank S, Gaume B, Bergmann-Leitner ES, et al. The role of dynamin-related protein1, a mediator of mitochondrial fission, in apoptosis. Dev. Cell 2001; 1:515-25.
  • Reddy PH, Reddy TP, Manczak M, et al. Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Res. Rev. 2011; 67:103-18.
Buffer:
DNM1L antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (100%)
Immunogen:
DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L.

The immunogen is located within amino acids 530 - 580 of DNM1L.
NCBI Gene ID #:
10059
NCBI Official Name:
dynamin 1-like
NCBI Official Symbol:
DNM1L
NCBI Organism:
homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 81 kDa

Observed: 80 kDa
Protein Accession #:
NP_036192
Protein GI Number:
171460914
Purification:
DNM1L antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
SPECIFICITY:
DNM1L antibody is human and mouse reactive. At least four isoforms of DNM1L are known to exist; this antibody will detect the two longest isoforms.
Swissprot #:
O00429
User NOte:
Optimal dilutions for each application to be determined by the researcher.