Further Information
CD8B, CD8B, LYT3, Leu2, Ly3, LY3, P37, LEU2, CD8B1
CD8B antibody can be used for detection of CD8B by ELISA at 1:312500. CD8B antibody can be used for detection of CD8B by western blot at 1.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. CD8B is the CD8 beta chain isoforms.The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
- Moody, A.M., (2003) J. Biol. Chem. 278 (9), 7240-7246.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CD8B.
926
CD8b molecule
CD8B
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
27 kDa, 24 kDa, 25 kDa, 24 kDa, 27 kDa, 20 kDa
NP_742097
27886631
Antibody is purified by peptide affinity chromatography method.
Q53QL8
Optimal dilutions for each application to be determined by the researcher.