ProSci

ABL1/2 Antibody

Product Code:
 
PSI-79-245
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
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Western blot analysis of lysed extracts from HL60 cells using ABL1/2 (phospho-Tyr393/429).
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<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ABL1/2 (Phospho-Tyr393/429).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using ABL1/2 (phospho-Tyr393/429).
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Western blot analysis of lysed extracts from HL60 cells using ABL1/2 (phospho-Tyr393/429).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ABL1/2 (Phospho-Tyr393/429).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using ABL1/2 (phospho-Tyr393/429).

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PSI-79-245-0.1mg0.1mg£488.00
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Further Information

Additional Names:
ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl, BHLHE39, Abelson murine leukemia viral oncogene homolog 1
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background:
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Background References:
  • Wang, J. Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N. N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B. B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ABL1/2 (phospho-Tyr393/429) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2.
Modifications:
Phospho-Specific
NCBI Gene ID #:
25 / 27
NCBI Official Name:
c-abl oncogene 1, non-receptor tyrosine kinase / c-abl oncogene 2, non-receptor tyrosine kinase
NCBI Official Symbol:
ABL1 ABL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
210 kDa
Protein Accession #:
NP_005148.2 / NP_001129472.1
Protein GI Number:
62362414 / 209862772
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Cell Cycle
SPECIFICITY:
This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.
Swissprot #:
P00519 P42684