ProSci

Ezrin Antibody

Product Code:
 
PSI-79-133
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
1 / 2
Western blot analysis of lysed extracts from 293 cells untreated or treated with EGF using Ezrin (Phospho-Tyr353).
2 / 2
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Ezrin (Phospho-Tyr353).
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Western blot analysis of lysed extracts from 293 cells untreated or treated with EGF using Ezrin (Phospho-Tyr353).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Ezrin (Phospho-Tyr353).

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PSI-79-133-0.1mg0.1mg£488.00
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Further Information

Additional Names:
CVL, CVIL, VIL2, HEL-S-105, ESR, NR3A1, Cytovillin, EZRI, Villin 2, p81
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Background References:
  • Zhao H, et al. (2004) Proc Natl Acad Sci U S A101 (25): 9485-9490. Wang Q, et al. (2003) J Biol Chem 278 (48): 47731-47743. Gautreau A, et al. (1999) Proc Natl Acad Sci U S A 96 (13): 7300-7305. Crepaldi T, et al. (1997) J Cell Biol 138 (2): 423-34.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Ezrin (Phospho-Tyr353) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 353 (Q-D-Y (p) -E-E) derived from Human EZRIN.
Modifications:
Phospho-Specific
NCBI Gene ID #:
7430
NCBI Official Name:
ezrin
NCBI Official Symbol:
EZR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
81 kDa
Protein Accession #:
NP_001104547.1
Protein GI Number:
161702986
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of Ezrin only when phosphorylated at tyrosine 353.
Swissprot #:
P15311