Further Information
p50, KBF1, p105, EBP-1, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B, SHC, SHCA, DNA-binding factor KBF1, NF-kappa-B1 p84/NF-kappa-B1 p98, NFKB1, NFkB-p50
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
- Hou S, et al. (2003) J Biol Chem. 278 (46): 45994-45998. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NFkB-p105/p50 (Phospho-Ser927) antibody was raised against a peptide sequence around phosphorylation site of serine 927 (C-D-S (p) -G-V) derived from Human NFκB-p105.
Phospho-Specific
4790
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
50, 120 kDa
NP_001158884.1
259155302
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific,Apoptosis,Cancer
This antibody detects endogenous level of NFκB-p105/p50 only when phosphorylated at serine 927.
P19838