ProSci

PKCdelta Antibody

Product Code:
 
PSI-79-229
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
1 / 2
Western blot analysis of lysed extracts from PC12 cells untreated or treated with PMA using PKCδ (Phospho-Ser645).
2 / 2
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PKCδ (Phospho-Ser645).
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Western blot analysis of lysed extracts from PC12 cells untreated or treated with PMA using PKCδ (Phospho-Ser645).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PKCδ (Phospho-Ser645).

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PSI-79-229-0.1mg0.1mg£488.00
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Further Information

Additional Names:
MAY1, PKCD, CVID9, nPKC-delta, BHLHC1, MYF3, MYOD, KPCD, PKC-delta, PRKCD, kinase PKC-delta
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.
Background References:
  • Kei Sakamoto, et, al. (2003) Am J Physiol Endocrinol Metab ; 285: E1081 - E1088. Ling Zhang, et, al. (2004) J. Biol. Chem ; 279: 28315 - 28319. Kristof Van Kolen et, al. (2006) FEBS J ; 273: 1843 - 1854. Martin Villalba, et, al. (2002) J. Cell Biol ; 157: 253.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PKCdelta (Phospho-Ser645) antibody was raised against a peptide sequence around phosphorylation site of serine 645 (R-L-S (p) -Y-S) derived from Human PKCδ.
Modifications:
Phospho-Specific
NCBI Gene ID #:
5580
NCBI Official Name:
protein kinase C, delta
NCBI Official Symbol:
PRKCD
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
78 kDa
Protein Accession #:
NP_006245.2
Protein GI Number:
31377782
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Apoptosis,Cancer,Neuroscience
SPECIFICITY:
This antibody detects endogenous level of PKCδ only when phosphorylated at serine 645.
Swissprot #:
Q05655