Further Information
CFC, NS1, SHP2, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, FRAP, FRAP1, FRAP2, RAFT1, RAPT1, PTN11, PTP-2C, PTPN11
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.
- Ferjoux G, et al. (2003) Mol Biol Cell. 2003; 14 (9): 3911-3928. Shi ZQ, et al. (2000) Mol Cell Biol. 20 (5): 1526-1536. Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96 (17): 9677-9682Manes S, et al. (1999) Mol Cell Biol. 19 (4): 3125-3135. Oh ES, et al. (1999) Mol Cell Biol; 19 (4): 3205-3215.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
SHP-2 (Phospho-Tyr542) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 542 (H-E-Y (p) -T-N) derived from Human SHP-2.
Phospho-Specific
5781
protein tyrosine phosphatase, non-receptor type 11
PTPN11
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
72 kDa
NP_002825.3
33356177
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific
This antibody detects endogenous level of SHP-2 only when phosphorylated at tyrosine 542.
Q06124