Antibody Clonality:
Polyclonal
Applications:- Immunohistochemistry (IHC)
- Western Blot (WB)
Storage:
Store antibody at -20˚C for up to one year.
1 / 2
2 / 2
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This product comes from:
United States.
Typical lead time:
14-21 working days.
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Further Information
BBC2, BCL2L8, ERBB, ERBB1, HER1, BBC6
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
- Zhang B, et al. (2004) . Mol Cell Biol. 24 (14): 6205-6214. Rice PL, et al. (2003) . Cancer Res. 63 (3): 616-620. Wang XQ, et al. (2001) . J Biol Chem. 276 (48): 44504-44511.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
BAD (Phospho-Ser112) antibody was raised against a peptide sequence around phosphorylation site of serine 112 (H-S-S (p) -Y-P) derived from Human BAD.
Phospho-Specific
572
BCL2-associated agonist of cell death
BAD
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
23 kDa
NP_004313.1
10835069
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Phospho-Specific,Apoptosis,Cancer
This antibody detects endogenous level of BAD only when phosphorylated at serine 112.
Q92934