ProSci

EGFR Antibody

Product Code:
 
PSI-79-141
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
1 / 2
Western blot analysis of lysed extracts from HUVEC cells untreated or treated with EGF using EGFR (Phospho-Ser1070).
2 / 2
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR (Phospho-Ser1070).
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Western blot analysis of lysed extracts from HUVEC cells untreated or treated with EGF using EGFR (Phospho-Ser1070).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR (Phospho-Ser1070).

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PSI-79-141-0.1mg0.1mg£488.00
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Further Information

Additional Names:
ERBB, HER1, mENA, ERBB1, PIG61, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
Background References:
  • Feinmesser RL, et al. (1999) J Biol Chem; 274 (23): 16168-73. Gamou S, et al. (1995) FEBS Lett; 357 (2): 161-4. Gamou S, et al. (1994) J Cell Physiol; 158 (1): 151-9. Heisermann GJ, et al. (1988) J Biol Chem; 263 (26): 13152-8.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
EGFR (Phospho-Ser1070) antibody was raised against a peptide sequence around phosphorylation site of serine 1070 (R-Y-S (p) -S-D) derived from Human EGFR.
Modifications:
Phospho-Specific
NCBI Gene ID #:
1956
NCBI Official Name:
epidermal growth factor receptor
NCBI Official Symbol:
EGFR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
175 kDa
Protein Accession #:
NP_005219.2
Protein GI Number:
29725609
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of EGFR only when phosphorylated at serine1070.
Swissprot #:
P00533