ProSci

Tau Antibody

Product Code:
 
PSI-79-153
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
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Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Ser404).
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<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer?s Disease using Tau (Phospho-Ser404).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using Tau (Phospho-Ser404).
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Western blot analysis of lysed extracts from mouse brain tissue using Tau (Phospho-Ser404).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer?s Disease using Tau (Phospho-Ser404).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using Tau (Phospho-Ser404).

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PSI-79-153-0.1mg0.1mg£488.00
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Further Information

Additional Names:
TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, MAPT, MTAPT, Neurofibrillary tangle protein, PHF-tau
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Background:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Background References:
  • Li G, Yin H, et. al . (2004) J Biol Chem ; 279 (16): 15938-45. Noble W, et al. (2003) Neuron ; 38 (4): 555-65. Giasson BI, et al. (2002) . Biochemistry; 41 (51): 15376-87. Lee G., et. al. (1989) . Neuron 2:1615-1624. Andreadis A. et. al. (1992) Biochemistry 31:10626-10633.
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Tau (Phospho-Ser404) antibody was raised against a peptide sequence around phosphorylation site of serine 404 (D-T-S (p) -P-R) derived from Human Tau.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4137
NCBI Official Name:
microtubule-associated protein tau
NCBI Official Symbol:
MAPT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48, 62, 78 kDa
Protein Accession #:
NP_001116538.1
Protein GI Number:
178557734
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific,Neuroscience
SPECIFICITY:
This antibody detects endogenous level of Tau only when phosphorylated at serine 404.
Swissprot #:
P10636