Further Information
PTK2B, PKB, PTK, CAKB, FAK2, PYK2, CADTK, FADK2, RAFTK
PTK2B antibody can be used for detection of PTK2B by ELISA at 1:312500. PTK2B antibody can be used for detection of PTK2B by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
- Ling, S., et al., (2004) Am. J. Cell Physiol. 287 (3), C698-C706.
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PTK2B.
2185
protein tyrosine kinase 2 beta
PTK2B
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
116 kDa
NP_004094
27886584
Antibody is purified by protein A chromatography method.
Cancer ,Signal Transduction ,Apoptosis
Q14289
Optimal dilutions for each application to be determined by the researcher.