Further Information
RHOC, ARH9, ARHC, H9, MGC1448, MGC61427, RHOH9
RHOC antibody can be used for detection of RHOC by ELISA at 1:62500. RHOC antibody can be used for detection of RHOC by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
RHOC Is a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. RHOC is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of RHOC is associated with tumor cell proliferation and metastasis.This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
- Sousa, J.F. (er) BMC Cancer 8, 19 (2008).
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
batch dependent
Unconjugated
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RHOC.
389
ras homolog family member C
RHOC
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
NP_786886
28395033
Antibody is purified by peptide affinity chromatography method.
Cancer ,Signal Transduction ,Immunology
P08134
Optimal dilutions for each application to be determined by the researcher.