Further Information
CFC3, MEK1, MKK1, MAPKK1, PRKMK1, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1, ERK activator kinase 1, MAP kinase kinase 1, MAP2K1, MAPK/ERK kinase 1, MAPKK 1
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
- Zebisch A, et al. (2006) Cancer Res; 66 (7): 3401-8. Luciano BS, et al. (2006) J Biol Chem; 279 (50): 52117-23. Wang X, et al. (2003) Oncogene; 22 (1): 109-16. Gopalbhai K, et al. (2003) J Biol Chem; 278 (10): 8118-25. Ling MT, et al. (2002) Oncogene; 21 (55): 8498-505.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
MEK1 (Ab-221) antibody was raised against a peptide sequence around aa.219~223 (A-N-S-F-V) derived from Human MEK1.
5604
mitogen-activated protein kinase kinase 1
MAP2K1
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
NP_002746.1
5579478
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Other
This antibody detects endogenous level of total MEK1 protein.
Q02750