Further Information
PAKalpha, CRSBP1, HAR, XLKD1, UNQ230/PRO263, p21-activated kinase 1, PAK-1, p65-PAK, Alpha-PAK
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
- Parsons M, et al. (2005) Mol Cell Biol ; 25:1680-1695. Jung JH, et al. (2005) J Biol Chem; 280:40025-40031. Lampugnani MG, et al. (2002) Mol Biol Cell ; 13: 1175-1189Wang RA, et al. (2002) EMBO J; 21: 5437 - 5447.
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
PAK1/PAK2/PAK3 (Ab-423/402/421) antibody was raised against a peptide sequence around aa.421~425/400~404/419~423 (R-S-T-M-V) derived from Human PAK1/PAK2/PAK3.
5058 / 5062 / 5063
p21 protein (Cdc42/Rac)-activated kinase 1 / p21 protein (Cdc42/Rac)-activated kinase 2 / p21 protein (Cdc42/Rac)-activated kinase 3
PAK1 PAK2 PAK3
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
61 - 67 (PAK2) 68 - 74 (PAK1/3) kDa
NP_001122092.1 / NP_002568.2 / NP_001121638.1
190886457 / 32483399 / 189491751
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Apoptosis,Cancer
This antibody detects endogenous level of total PAK1/PAK2/PAK3 protein.
Q13153//Q13177//O75914