Further Information
SMC1, SMCB, CDLS2, SB1.8, SMC1L1, DXS423E, SMC1alpha, ESR, NR3A1, SM1A, SMC1A, SMC1 alpha protein
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
- Yang XM. et al. (2004) Mol Cell Biol. 24 (12): 5290-5303. Kim ST. et al. (2002) Genes Dev. 16 (5): 560-570. Revenkova E. et al. (2001) Mol Cell Biol. 21 (20): 6984-6998
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
1 mg/mL
Unconjugated
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
SMC1 (Ab-957) antibody was raised against a peptide sequence around aa. 955~959 (G-S-S-Q-G) derived from Human SMC1.
8243
structural maintenance of chromosomes 1A
SMC1A
Homo sapiens
Liquid
PREDICTED MOLECULAR WEIGHT:
145 kDa
NP_006297.2
30581135
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Cell Cycle
This antibody detects endogenous level of total SMC1 protein.
Q14683